Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner-Reference-Cited by-同舟云学术

Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner

Published:2022-05-19 Issue:5 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Andresen Silke¹²,Fantone Kayla³,Chapla Digantkumar²⁴,Rada Balázs³^ORCID,Moremen Kelley W.²⁴,Pierce Michael²⁴,Szymanski Christine M.¹²^ORCID

Affiliation:

1. Department of Microbiology, University of Georgia, Athens, Georgia, USA

2. Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA

3. Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA

4. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA

Abstract

Human intelectin-1 (hIntL-1) is a secreted glycoprotein capable of binding exocyclic 1,2-diols within surface glycans of human pathogens such as Streptococcus pneumoniae , Vibrio cholerae , and Helicobacter pylori . For the latter, lectin binding was shown to cause bacterial agglutination and increased phagocytosis, suggesting a role for hIntL-1 in pathogen surveillance.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00682-21

Reference59 articles.

1. The mannose-binding lectin: a prototypic pattern recognition molecule

2. Cutting Edge: Complement-Activating Complex of Ficolin and Mannose-Binding Lectin-Associated Serine Protease

3. Low Invasiveness of Pneumococcal Serotype 11A Is Linked to Ficolin-2 Recognition of O-acetylated Capsule Epitopes and Lectin Complement Pathway Activation