Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages-Reference-Cited by-同舟云学术

Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Guan Fei¹,Jiang Wangfang²,Bai Yang¹,Hou Xiao³,Jiang Chunjie¹,Zhang Chongyang¹,Jacques Muziazia Lupemba⁴,Liu Wenqi¹,Lei Jiahui¹^ORCID

Affiliation:

1. Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2. Department of Clinical Laboratory, Changzhi People’s Hospital, Changzhi, China

3. Department of Clinical Laboratory, General Hospital of Central Theater Command, PLA, Wuhan, China

4. Department of Parasitology, School of Basic Medicine, Institute of Medical Technology, Kinshasa, Democratic Republic of the Congo

Abstract

Trichinellosis is one of most neglected foodborne zoonoses worldwide. During Trichinella spiralis infection, the intestinal immune response is the first line of defense and plays a vital role in the host’s resistance.

Funder

The National Nature Science Fundation of China

The Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00683-20

Reference44 articles.

1. Parasites in Food: From a Neglected Position to an Emerging Issue

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3. Protective immunity in mice vaccinated with a novel elastase-1 significantly decreases Trichinella spiralis fecundity and infection

4. The P2X7 Receptor in Infection and Inflammation

5. The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )

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