Virulence Traits of a Serogroup C Meningococcus and Isogenic cssA Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis-Reference-Cited by-同舟云学术

Virulence Traits of a Serogroup C Meningococcus and Isogenic cssA Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Colicchio Roberta¹,Pagliuca Chiara¹,Ricci Susanna²,Scaglione Elena¹,Grandgirard Denis³^ORCID,Masouris Ilias⁴,Farina Fabrizio⁵,Pagliarulo Caterina⁶,Mantova Giuseppe¹,Paragliola Laura⁷,Leib Stephen L.³^ORCID,Koedel Uwe⁴,Pozzi Gianni²,Alifano Pietro⁸,Salvatore Paola¹⁷⁹

Affiliation:

1. Department of Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy

2. Laboratory of Molecular Microbiology and Biotechnology (LAMMB), Department of Medical Biotechnologies, University of Siena, Siena, Italy

3. Institute for Infectious Diseases, University of Bern, Bern, Switzerland

4. Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany

5. Department of Law, Economics, Management and Quantitative Methods, University of Sannio, Benevento, Italy

6. Department of Science and Technology, Sannio University, Benevento, Italy

7. Department of Integrated Activity of Laboratory Medicine and Transfusion, Complex Operative Unit of Clinical Microbiology, University Hospital Federico II, Naples, Italy

8. Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy

9. CEINGE, Biotecnologie Avanzate s.c.ar.l., Naples, Italy

Abstract

In serogroup C Neisseria meningitidis , the cssA ( siaA ) gene codes for an UDP- N -acetylglucosamine 2-epimerase that catalyzes the conversion of UDP- N -acetyl-α- d -glucosamine into N -acetyl- d -mannosamine and UDP in the first step in sialic acid biosynthesis. This enzyme is required for the biosynthesis of the (α2→9)-linked polysialic acid capsule and for lipooligosaccharide (LOS) sialylation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00688-18

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