High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic

Author:

Metzger W1,Mordmüller B1,Graninger W1,Bienzle U1,Kremsner P G1

Affiliation:

1. International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon.

Abstract

In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference13 articles.

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3. Susceptibility of P. falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation to chloroquine;Björkman A.;Liberia. Bull. W. H. O.,1991

4. Short term cinchona alkaloids regimens for treatment of falciparum malaria;Deloron P.;Madagascar. Trans. R. Soc. Trop. Med. Hyg.,1990

5. Intravenous quinine therapy of hospitalized children with P. falciparum malaria in Kinshasa, Zaire;Greenberg A. E.;Am. J. Trop. Med. Hyg.,1989

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