Affiliation:
1. International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon.
Abstract
In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Tratamento da malaria (P. falciparum) com clindamicina. II. Esquema posol~ogico em cinco dias;Alecrim W. D.;Rev. Inst. Med. Trop. So Paolo,1982
2. Emprego da associaco tetraciclina e quinino no tratamento da malaria causada pelo P. falciparum;Barata L. C. B.;Rev. Soc. Bras. Med. Trop.,1986
3. Susceptibility of P. falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation to chloroquine;Björkman A.;Liberia. Bull. W. H. O.,1991
4. Short term cinchona alkaloids regimens for treatment of falciparum malaria;Deloron P.;Madagascar. Trans. R. Soc. Trop. Med. Hyg.,1990
5. Intravenous quinine therapy of hospitalized children with P. falciparum malaria in Kinshasa, Zaire;Greenberg A. E.;Am. J. Trop. Med. Hyg.,1989
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献