Author:
Kaci Ghalia,Goudercourt Denise,Dennin Véronique,Pot Bruno,Doré Joël,Ehrlich S. Dusko,Renault Pierre,Blottière Hervé M.,Daniel Catherine,Delorme Christine
Abstract
ABSTRACTStreptococcus salivariusis one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential ofS. salivariuswas first evaluatedin vitroon human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that liveS. salivariusstrains inhibitedin vitrothe activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the liveS. salivariusJIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. Thesein vitroandin vivoanti-inflammatory properties were not found with heat-killedS. salivarius, suggesting a protective response exclusively with metabolically active bacteria.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference44 articles.
1. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut;Artis;Nat. Rev. Immunol.,2008
2. Probiotics, nuclear receptor signaling, and anti-inflammatory pathways;Yoon;Gastroenterol. Res. Pract.,2011
3. The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives;Wan;Cell Res.,2010
4. Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: adhesion properties, competition against enteropathogens and modulation of IL-8 production;Candela;Int. J. Food Microbiol.,2008
5. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation;Lin;Free Radic. Biol. Med.,2009
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