Nitric Oxide Inhibition of Rickettsia rickettsii-Reference-Cited by-同舟云学术

Nitric Oxide Inhibition of Rickettsia rickettsii

Published:2021-11-16 Issue:12 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fitzsimmons Liam F.¹,Clark Tina R.¹,Hackstadt Ted¹^ORCID

Affiliation:

1. Host-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Abstract

Rickettsia rickettsii , the causative agent of Rocky Mountain spotted fever, is an enzootic, obligate, intracellular bacterial pathogen. Nitric oxide (NO) synthesized by the inducible NO synthase (iNOS) is a potent antimicrobial component of innate immunity and has been implicated in the control of virulent Rickettsia spp. in diverse cell types.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00371-21

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4. Dr. NO and Mr. Toxic – the versatile role of nitric oxide

5. Inducible nitric oxide synthase: Regulation, structure, and inhibition

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