Primary Role of Suppressor of Cytokine Signaling 1 in Mycobacterium bovis BCG Infection-Reference-Cited by-同舟云学术

Primary Role of Suppressor of Cytokine Signaling 1 in Mycobacterium bovis BCG Infection

Published:2018-11 Issue:11 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Soma Shogo¹²,Kawai Satoru³,Inada Hiroyasu⁴,Watanabe Kenta⁵,Mizuno Satoru¹⁶,Kato Seiichi²⁶,Matsuo Kazuhiro⁶,Yasutomi Yasuhiro¹²

Affiliation:

1. Department of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, Japan

2. Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Ibaraki, Japan

3. Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, Japan

4. Faculty of Pharmaceutical Science, Department of Pathology, Suzuka University of Medical Science, Minamitamagaki, Suzuka, Mie, Japan

5. Joint Faculty of Veterinary Medicine, Laboratory of Veterinary Public Health, Yamaguchi University, Oaza Yoshida, Yamaguchi, Japan

6. Research and Development Department, Japan BCG Laboratory, Matsuyama, Kiyose, Tokyo, Japan

Abstract

Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of JAK/STAT signaling and is induced by mycobacterial infection. To understand the major function of SOCS1 during infection, we established a novel system in which recombinant Mycobacterium bovis bacillus Calmette-Guérin expressed dominant-negative SOCS1 (rBCG-SOCS1DN) because it would not affect the function of SOCS1 in uninfected cells.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00376-18

Reference43 articles.

1. Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii

2. Cross-Talk between Programmed Death-1 and Suppressor of Cytokine Signaling-1 in Inhibition of IL-12 Production by Monocytes/Macrophages in Hepatitis C Virus Infection

3. Expression of Suppressor of Cytokine Signaling 1 (SOCS1) Impairs Viral Clearance and Exacerbates Lung Injury during Influenza Infection

4. Inhibition of Reactive Oxygen Species Production Ameliorates Inflammation Induced by Influenza A Viruses via Upregulation of SOCS1 and SOCS3

5. Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1

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