Comparative Study of Immunogenic Properties of Purified Capsular Polysaccharides from Streptococcus suis Serotypes 3, 7, 8, and 9: the Serotype 3 Polysaccharide Induces an Opsonizing IgG Response-Reference-Cited by-同舟云学术

Comparative Study of Immunogenic Properties of Purified Capsular Polysaccharides from Streptococcus suis Serotypes 3, 7, 8, and 9: the Serotype 3 Polysaccharide Induces an Opsonizing IgG Response

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Goyette-Desjardins Guillaume¹²³^ORCID,Auger Jean-Philippe¹²³,Dolbec Dominic¹²³,Vinogradov Evgeny⁴,Okura Masatoshi⁵,Takamatsu Daisuke⁵⁶,Van Calsteren Marie-Rose¹⁷,Gottschalk Marcelo¹²³,Segura Mariela¹²³^ORCID

Affiliation:

1. Swine and Poultry Infectious Diseases Research Centre, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada

2. Research Group on Infectious Diseases in Production Animals, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada

3. Canadian Glycomics Network (GlycoNet), University of Alberta, Edmonton, Alberta, Canada

4. National Research Council, Ottawa, Ontario, Canada

5. Division of Bacterial and Parasitic Disease, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

6. The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu, Japan

7. Saint-Hyacinthe Research and Development Centre, Agriculture and Agri-Food Canada, Saint-Hyacinthe, Quebec, Canada

Abstract

Streptococcus suis is an encapsulated bacterium and one of the most important swine pathogens and a zoonotic agent for which no effective vaccine exists. Bacterial capsular polysaccharides (CPSs) are poorly immunogenic, but anti-CPS antibodies are essential to the host defense against encapsulated bacteria. In addition to the previously known serotypes 2 and 14, which are nonimmunogenic, we have recently purified and described the CPS structures for serotypes 1, 1/2, 3, 7, 8, and 9.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

U of A | Canadian Glycomics Network

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00377-20

Reference82 articles.

1. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?

2. Streptococcus suis, an important pig pathogen and emerging zoonotic agent—an update on the worldwide distribution based on serotyping and sequence typing