Identification of an Autorepressing Two-Component Signaling System That Modulates Virulence in Streptococcus suis Serotype 2-Reference-Cited by-同舟云学术

Identification of an Autorepressing Two-Component Signaling System That Modulates Virulence in Streptococcus suis Serotype 2

Published:2019-09 Issue:9 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhong Xiaojun¹²³,Zhang Yue¹²³,Zhu Yinchu¹²³,Dong Wenyang¹²³,Ma Jiale¹²³,Pan Zihao¹²³,Yao Huochun¹²³

Affiliation:

1. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

2. OIE Reference Laboratory for Swine Streptococcosis, Nanjing, China

3. Key Laboratory of Animal Bacteriology, Ministry of Agriculture, Nanjing, China

Abstract

Streptococcus suis is one of the most important pathogens affecting the swine industry and is also an emerging zoonotic agent for humans. Two-component signaling systems (TCSs) play important roles in the adaptation of pathogenic bacteria to host environments. In this study, we identified a novel TCS, named TCS09HKRR, which facilitated Streptococcus suis serotype 2 (SS2) resistance to clearance by the host immune system and contributed to bacterial pathogenicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00377-19

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