An influenza virus inhibitor that acts late in the replication cycle

Author:

Antonelli G,Dianzani F,Coppenhaver D H,Baron S,Calandra P,Folchitto G

Abstract

An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, less than 1,000).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. Inhibition of varicella-zoster virus replication by Neuramide;Albrecht T. B.;Chemioterapia,1983

2. Studio su un inibitore del virus della varicella-Zoster;Albrecht T. B.;G. Ital. Chemioter.,1980

3. Broadly active inhibitor of viruses spontaneously produced by many cell types in culture;Baron S.;Infect. Immun.,1981

4. Size and stability of a naturally occurring virus inhibitor;Coppenhaver D. H.;Antimicrob. Agents Chemother.,1984

5. Non-interferon cellular products capable of virus inhibition;Kumar S.;Tex. Rep. Biol. Med.,1981

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