The Human Cytomegalovirus Protein UL116 Interacts with the Viral Endoplasmic-Reticulum-Resident Glycoprotein UL148 and Promotes the Incorporation of gH/gL Complexes into Virions-Reference-Cited by-同舟云学术

The Human Cytomegalovirus Protein UL116 Interacts with the Viral Endoplasmic-Reticulum-Resident Glycoprotein UL148 and Promotes the Incorporation of gH/gL Complexes into Virions

Published:2021-07-12 Issue:15 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Siddiquey Mohammed N. A.¹^ORCID,Schultz Eric P.²³^ORCID,Yu Qin²⁴³,Amendola Diego⁵,Vezzani Giacomo⁵,Yu Dong⁶,Maione Domenico⁵,Lanchy Jean-Marc²,Ryckman Brent J.²⁷⁴³^ORCID,Merola Marcello⁵⁸^ORCID,Kamil Jeremy P.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA

2. Division of Biological Sciences, University of Montana, Missoula, Montana, USA

3. Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, Montana, USA

4. Biochemistry and Biophysics Program, University of Montana, Missoula, Montana, USA

5. GSK, Siena, Italy

6. GSK, Rockville, Maryland, USA

7. Cellular, Molecular and Microbial Biology Program, University of Montana, Missoula, Montana, USA

8. University of Naples Federico II, Naples, Italy

Abstract

HCMV is a betaherpesvirus that causes dangerous opportunistic infections in immunocompromised patients as well as in the immune-naive fetus and preterm infants. The potential of the virus to enter new host cells is governed in large part by two alternative viral glycoprotein H (gH)/glycoprotein L (gL) complexes that play important roles in entry: gH/gL/gO and gH/gL/UL128-131.

Funder

American Heart Association

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02207-20

Reference44 articles.

1. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry