Acid Phosphatase Cytochemistry of Phagocytizing Leukocytes from Patients with Chronic Granulomatous Disease

Author:

Douglas Steven D.1,Spicer S. S.2

Affiliation:

1. Department of Medicine, Mount Sinai School of Medicine, of The City University of New York, New York, New York 10029

2. Department of Pathology, Medical University of South Carolina, Charleston, South Carolina 29401

Abstract

Studies of neutrophils and eosinophils from normal individuals, patients with chronic granulomatous disease of childhood, and their heterozygous mothers demonstrate degranulation and vacuolization during phagocytosis of opsonized Escherichia coli . Acid phosphatase reactivity is demonstrated in some primary granules of neutrophils and around crystalloids of some eosinophil granules and is comparable for cells from the three groups of individuals studied. Strong acid phosphatase reactivity is consistently demonstrated in phagocytic vacuoles of both cell types in cells from normal and affected individuals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference22 articles.

1. Motion picture studies on degranulation of horse eosinophils during phagocytosis;Archer G. T.;J. Exp. Med.,1963

2. Degranulation of leukocytes in chronic granulomatous disease;Baehner R. L.;J. Clin. Invest.,1969

3. Quantitative nitroblue tetrazolium test in chronic granulomatous disease;Baehner R. L.;N. Engl. J. Med.,1968

4. Baehner R. L. D. G. Nathan and M. L. Karnovsky. 1970.

5. Histochemical methods for acid phosphatase using hexazonium pararosanilin as coupler;Barka T.;J. Histochem. Cytochem.,1962

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1. Advantages of histochemistry for the study of cell biology;The Histochemical Journal;1993-08

2. Stimulated intraphagosomal release of eosinophil peroxidase and acid phosphatase in the rats spontaneously infected with Mycoplasma pulmonis: A cytochemical study;Experimental and Molecular Pathology;1989-12

3. Inborn Errors of Oxygen-Dependent Microbial Killing by Neutrophils;Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics;1984

4. Immune Status of the Malnourished Host;Immunological Aspects of Infectious Diseases;1979

5. The Eosinophil and its Role in Immunity to Helminth Infection;Current Topics in Microbiology and Immunology;1977

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