Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice-Reference-Cited by-同舟云学术

Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice

Published:2023-01-24 Issue:1 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Popov Georgy¹^ORCID,Fiebig-Comyn Aline²³,Syriste Lukas¹,Little Dustin J.²³⁴^ORCID,Skarina Tatiana⁵,Stogios Peter J.⁵,Birstonas Sarah⁴,Coombes Brian K.²³^ORCID,Savchenko Alexei¹⁵^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

3. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

4. Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada

5. Department of Chemical Engineering and Applied Chemistry, Toronto University, Toronto, Ontario, Canada

Abstract

The NleGs are the largest family of type 3 secreted effectors in attaching and effacing (A/E) pathogens, such as enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli , and Citrobacter rodentium . NleG effectors contain a conserved C-terminal U-box domain acting as a ubiquitin protein ligase and target host proteins via a variable N-terminal portion.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00505-22

Reference64 articles.

1. Escherichia coli O157:H7 Gastroenteritis and the Hemolytic Uremic Syndrome: An Emerging Infectious Disease

2. Citrobacter rodentium mouse model of bacterial infection