Chlamydia trachomatis Infection of Human Mesothelial Cells Alters Proinflammatory, Procoagulant, and Fibrinolytic Responses-Reference-Cited by-同舟云学术

Chlamydia trachomatis Infection of Human Mesothelial Cells Alters Proinflammatory, Procoagulant, and Fibrinolytic Responses

Published:1998-05 Issue:5 Volume:66 Page:2352-2355
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

van Westreenen Mireille¹,Pronk Apollo¹,Diepersloot Rob J. A.²,de Groot Philip G.³,Leguit Piet¹

Affiliation:

1. Departments ofSurgery1 and

2. Microbiology,2 Diakonessen Hospital, and

3. Department of Hematology, The University Hospital Utrecht,3 Utrecht, The Netherlands

Abstract

ABSTRACT In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the activity of the fibrinolytic inhibitor (plasminogen activator inhibitor 1) in the supernatants were enhanced. These findings support the hypothesis that provoked proinflammatory responses contribute to the development of complications after chlamydial infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.5.2352-2355.1998

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