Target Volume Analysis of Vaccinia Virus: Influence of Virus Dispersion and Noninfectious Particles-Reference-Cited by-同舟云学术

Target Volume Analysis of Vaccinia Virus: Influence of Virus Dispersion and Noninfectious Particles

Published:1968-10 Issue:10 Volume:2 Page:1102-1106
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Contreras Guillermo¹,Ohlbaum Adela¹

Affiliation:

1. Department of Virology, Faculty of Medicine, and Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile

Abstract

These data indicate that 90% of monodisperse vaccinia virus (VV) has a D 37 dose of 1.0 × 10 4 ± 0.2 × 10 4 rad when exposed to the direct effect of gamma radiation from 137 Cs and 60 Co sources. This D 37 dose yielded a targt size of approximately 10 8 daltons, close to the molecular weight of VV deoxyribonucleic acid. This target corresponds to the first component of the survival curve of VV. Noninfectious virus seemed to play a role on the slope and the proportion of the survival curve second component, suggesting that multiplicity reactivation takes place.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.2.10.1102-1106.1968

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