Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori-Reference-Cited by-同舟云学术

Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori

Published:1999-06 Issue:6 Volume:43 Page:1497-1499
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Heep Markus¹,Beck Daniela¹,Bayerdörffer Ekkehard²,Lehn Norbert¹

Affiliation:

1. Institut für Medizinische Mikrobiologie, Universitätsklinikum Regensburg, D-93053, Regensburg,1 and

2. Department of Internal Medicine I, Universitätsklinikum Carl Gustav Carus, D-01307 Dresden,2 Germany

Abstract

ABSTRACT Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 μg/ml; MIC at which 50% of isolates are inhibited [MIC 50 ], 0.25 μg/ml). The MIC 50 of rifabutin was 0.008 μg/ml ( n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.6.1497

Reference13 articles.

1. Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability

2. RNA polymerase (rpoB) mutants selected for increased resistance to gyrase inhibitors in Salmonella typhimurium.;Blanc-Potard A. B.;Mol. Gen. Genet.,1995

3. Molecular evolution of rifampicin resistance in Streptococcus pneumoniae.;Enright M.;Microb. Drug Resist.,1998

4. Antimicrobial activity of rifabutin.;Kunin C. M.;Clin. Infect. Dis.,1996

5. National Committee for Clinical Laboratory Standards Approved standard M7-A4. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 1997 National Committee for Clinical Laboratory Standards Wayne Pa

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