Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance-Reference-Cited by-同舟云学术

Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

Published:1999-06 Issue:6 Volume:43 Page:1500-1502
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chou Sunwen¹,Lurain Nell S.²,Weinberg Adriana³,Cai Guang-Yung³,Sharma Prem L.⁴,Crumpacker Clyde S.⁴,

Affiliation:

1. VA Medical Center, Portland, Oregon1;

2. Rush Medical Center, Chicago, Illinois2;

3. University of Colorado Health Sciences Center, Denver, Colorado3; and

4. Beth-Israel Deaconess Medical Center, Boston, Massachusetts4

Abstract

ABSTRACT The polymerase ( pol ) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.6.1500

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