Affiliation:
1. Department of Microbiology, Cleveland Clinic Foundation, Ohio 44195.
Abstract
The Genetic Systems Corp. Integra HIV-1 Pageblot system was evaluated as a supplementary assay to confirm the presence of antibodies to human immunodeficiency virus type 1 in 57 specimens from individuals at high risk of infection with the virus. Forty-one specimens identified as reactive in the Genetic Systems Integra HIV-1 Pageblot system were likewise identified as reactive in a U.S. Food and Drug Administration-licensed (Biotech/Dupont) Western blot (immunoblot). Six specimens identified as indeterminate in either or both immunoblot assays were all identified as nonreactive in a U.S. Food and Drug Administration-licensed enzyme immunoassay with recombinant antigens.
Publisher
American Society for Microbiology
Reference20 articles.
1. Bibberfeld G. U. Bredenberg-Raden B. Bottiger P. 0. Putkonen J. Blomberg P. Juto and G. Widell. 1986. Blood donor sera with false positive Western blot reactions in human immunodeficiency virus. Lancet ii:289-290.
2. Serological diagnosis of human immunodeficiency virus infection by Western blot testing;Carlson J. R.;J. Am. Med. Assoc.,1988
3. Update: serologic testing for antibody to human immunodeficiency virus;Centers for Disease Control.;Morbid. Mortal. Weekly Rep.,1988
4. Centers for Disease Control. 1989. Interpretation and use of the Western blot assay for serodiagnosis of human immunodeficiency virus type 1 infections. Morbid. Mortal. Weekly Rep. 38(Suppl. S-7):1-7.
5. False-positive autoantibodies in HIV infection;Davenport A.;Lancet,1990