Effects of N -Hydroxyurethan on Viability and Metabolism of Escherichia coli-Reference-Cited by-同舟云学术

Effects of N -Hydroxyurethan on Viability and Metabolism of Escherichia coli

Published:1971-02 Issue:2 Volume:105 Page:556-564
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Mullinix Kathleen P.¹,Rosenkranz Herbert S.¹

Affiliation:

1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Abstract

Exposure of growing cells to low levels of N -hydroxyurethan (approximately 0.05 m ) resulted in loss of colony-forming ability. This was accompanied by degradation of cellular deoxyribonucleic acid. When the concentration of N -hydroxyurethan was increased to 0.2 m , bacteriostasis was the primary manifestation. The lethal action of the drug was prevented by contreatment with chloramphenicol or azauracil or by uracil-deprivation of a bacterial strain requiring this pyrimidine for growth.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.105.2.556-564.1971

Reference46 articles.

1. Activity of congeners of hydroxyurea against advanced leukemia L-1210;Adamson R. H.;Proc. Soc. Exp. Biol. Med.,1965

2. Fractionation of deoxyribonucleic acids on columns of anion exchangers; methodology;Bendich A.;J. Amer. Chem. Soc.,1958

3. Skin-initiating action and Iung carcinogenesis by derivatives of urethan and related compounds;Berenblum I.;Biochem. Pharmacol.,1959

4. Changes in the structure and activity of A DNA in a superinfected immune bacterium;Bode V. C.;J. Mol. Biol.,1965

5. Chromosomal aberrations induced by hyponitrite and hydroxylamine derivatives;Borenfreund E.;J. Nat. Cancer Inst.,1964

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