Mechanism of Action of 4-Phenoxyphenoxyethyl Thiocyanate (WC-9) against Trypanosoma cruzi , the Causative Agent of Chagas’ Disease-Reference-Cited by-同舟云学术

Mechanism of Action of 4-Phenoxyphenoxyethyl Thiocyanate (WC-9) against Trypanosoma cruzi , the Causative Agent of Chagas’ Disease

Published:2003-06 Issue:6 Volume:47 Page:2047-2050
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Urbina Julio A.¹,Concepcion Juan Luis²,Montalvetti Andrea³,Rodriguez Juan B.⁴,Docampo Roberto³

Affiliation:

1. Laboratorio de Quimica Biológica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Carretera Panamericana, Caracas 1020

2. Laboratorio de Enzimología de Parásitos, Departamento de Biologia, Facultad de Ciencias, Universidad de Los Andes, La Hechicera, Merida, Venezuela

3. Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802

4. Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, RA-1428 Buenos Aires, Argentina

Abstract

ABSTRACT We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi , the etiological agent of Chagas’ disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.6.2047-2050.2003

Reference25 articles.

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