Specificity of QuantiFERON-TB Plus, a New-Generation Interferon Gamma Release Assay

Author:

Siegel S. A. R.1ORCID,Cavanaugh M.2,Ku J. H.1,Kawamura L. M.3,Winthrop K. L.14

Affiliation:

1. School of Public Health, Oregon Health & Science University-Portland State University, Portland, Oregon, USA

2. Oregon State Public Health Laboratory, Hillsboro, Oregon, USA

3. Qiagen, Germantown, Maryland, USA

4. Division of Infectious Diseases, Oregon Health & Science University, Portland, Oregon, USA

Abstract

Interferon gamma release assays (IGRAs) are important tools in identifying prior tuberculosis exposure. The new-generation QuantiFERON-TB Gold Plus (QFT-Plus) assay, recently approved for use in the United States, differs from the current-generation QFT Gold-In-Tube (QFT-GIT) assay with the addition of a second antigen tube that also contains novel CD8 + T-cell-stimulating peptides.

Funder

QIAGEN

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference31 articles.

1. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis

2. Qiagen. 2013. QuantiFERON TB Gold (QFT) ELISA package insert. Qiagen, Hilden, Germany. http://www.quantiferon.com/irm/content/PI/QFT/2PK/UK.pdf. Accessed 7 October 2016.

3. Qiagen. 2015. QuantiFERON-TB Gold Plus ELISA package insert. Qiagen, Hilden, Germany http://www.quantiferon.com/irm/content/package-inserts.aspx. Accessed 7 October 2016.

4. Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis;Lalvani A;Proc Natl Acad Sci U S A,1998

5. Classically Restricted Human CD8+T Lymphocytes Derived fromMycobacterium tuberculosis-Infected Cells: Definition of Antigenic Specificity

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