Pathogen Detection in Infective Endocarditis Using Targeted Metagenomics on Whole Blood and Plasma: a Prospective Pilot Study-Reference-Cited by-同舟云学术

Pathogen Detection in Infective Endocarditis Using Targeted Metagenomics on Whole Blood and Plasma: a Prospective Pilot Study

Published:2022-09-21 Issue:9 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Flurin Laure¹²^ORCID,Wolf Matthew J.¹,Fisher Cody R.¹^ORCID,Cano Cevallos Edison J.³⁴^ORCID,Vaillant James J.¹³,Pritt Bobbi S.¹³^ORCID,DeSimone Daniel C.³⁵,Patel Robin¹³^ORCID

Affiliation:

1. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

2. Department of Intensive Care, University Hospital of Guadeloupe, Pointe-à-Pitre, France

3. Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA

4. Memorial Healthcare System, Hollywood, Florida, USA

5. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA

Abstract

Initial microbiologic diagnosis of infective endocarditis (IE) relies on blood cultures and Bartonella and Coxiella burnetii serology. Small case series and one prospective study have preliminarily reported application of metagenomic sequencing on blood or plasma for IE diagnosis.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Mayo Clinic

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.00621-22

Reference30 articles.

1. Trends in Infective Endocarditis Incidence, Microbiology, and Valve Replacement in the United States From 2000 to 2011

2. Infective endocarditis