Affiliation:
1. Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg 24061-0305, USA.
Abstract
The fecal floras of polyp patients, Japanese-Hawaiians, North American Caucasians, rural native Japanese, and rural native Africans were compared. The polyp patients and Japanese-Hawaiians were considered to be groups at high risk of colon cancer, and the rural native Japanese and rural native Africans were considered to be groups at low risk. The North American Caucasians were found to have a flora composition intermediate between these two groups. Fifteen bacterial taxa from the human fecal flora were significantly associated with high risk of colon cancer, and five were significantly associated with low risk of colon cancer. Total concentrations of Bacteroides species and, surprisingly, Bifidobacterium species were generally positively associated with increased risk of colon cancer. Some Lactobacillus species and Eubacterium aerofaciens, which also produces major amounts of lactic acid, showed closest associations with low risk of colon cancer.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference17 articles.
1. Clues to the pathogenesis of familial colorectal cancer;Aaltonen L. A.;Science,1993
2. Drasar B. S. and M. J. Hill. 1974. Human intestinal flora p. 193-222. Academic Press Inc. New York.
3. Finegold S. M. 1977. Anaerobic bacteria in human disease p. 586-588. Academic Press Inc. New York.
4. Effect of diet on human fecal flora: comparison of Japanese and American diets;Finegold S. M.;Am. J. Clin. Nutri.,1974
5. The population frequencies of species, and the estimation of population parameters;Good I. J.;Biometrica,1953
Cited by
405 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献