Efficacy of Nanoencapsulated Daptomycin in an Experimental Methicillin-Resistant Staphylococcus aureus Bone and Joint Infection Model

Author:

Jacqueline Cedric12ORCID,Caillon Jocelyne12,Meyer Olivier3,Dailly Eric45,Simonsson Carl3,Lenaerts Vincent6,Asehnoune Karim17,Reghal Amokrane2,Potel Gilles12

Affiliation:

1. Université de Nantes, EA3826, IRS2 Nantes Biotech, Nantes, France

2. Atlangram, IRS2 Nantes Biotech, Nantes, France

3. Carlina Technologies, Angers, France

4. CHU Nantes, Service de Pharmacologie, Nantes, France

5. Université Nantes, MIHAR, IRS2 Nantes Biotech, Nantes, France

6. Trochylus Pharma Inc., Mississauga, Ontario, Canada

7. CHU Nantes, Pôle Anesthésie-Réanimation, Service d’Anesthésie Réanimation Chirurgicale, Nantes, France

Abstract

Staphylococcus aureus bone infections remain a therapeutic challenge, leading to long and expensive hospitalizations. Systemic antibiotic treatments are inconsistently effective, due to insufficient penetration into the infectious site.

Funder

Atlangram Biotech

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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