Author:
Samuel Dharmaraj,Xing Weimei,Niedziela-Majka Anita,Wong Jinny S.,Hung Magdeleine,Brendza Katherine M.,Perron Michel,Jordan Robert,Sperandio David,Liu Xiaohong,Mackman Richard,Sakowicz Roman
Abstract
ABSTRACTGS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproducedin vitrousing a purified, truncated respiratory syncytial virus (RSV) fusion protein. GS-5806 blocked these conformational changes, suggesting a possible mechanism for antiviral activity.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
32 articles.
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