Affiliation:
1. Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033.
Abstract
Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less than or equal to 2.0 micrograms/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference23 articles.
1. Appelbaum P. C. 1987. Anaerobic infections: nonsporeformers p. 45-109. In B. B. Wentworth (coordinating ed.) Diagnostic procedures for bacterial infections. American Public Health Association Washington D.C.
2. Comparative activity of 1-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ,-lactams against P-lactamase-producing anaerobes;Appelbaum P. C.;Antimicrob. Agents Chemother.,1986
3. Characterization of 13-lactamases from non-Bacteroides fragilis group Bacteroides spp. belonging to seven species and their role in 1-lactam resistance;Appelbaum P. C.;Antimicrob. Agents Chemother.,1990
4. Evaluation of two methods for rapid testing for beta-lactamase production in Bacteroides and;Appelbaum P. C.;Fusobacterium. Eur. J. Clin. Microbiol. Infect. Dis.,1990
5. 1-Lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers;Appelbaum P. C.;Antimicrob. Agents Chemother.,1990
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献