Human Herpesvirus 8 DNA Load in Leukocytes of Human Immunodeficiency Virus-Infected Subjects: Correlation with the Presence of Kaposi’s Sarcoma and Response to Anticytomegalovirus Therapy-Reference-Cited by-同舟云学术

Human Herpesvirus 8 DNA Load in Leukocytes of Human Immunodeficiency Virus-Infected Subjects: Correlation with the Presence of Kaposi’s Sarcoma and Response to Anticytomegalovirus Therapy

Published:1999-02 Issue:2 Volume:43 Page:377-380
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Boivin Guy¹²,Gaudreau Annie¹,Toma Emil³,Lalonde Richard⁴,Routy Jean-Pierre⁴,Murray Gilles²,Handfield Julie¹,Bergeron Michel G.¹²

Affiliation:

1. Infectious Disease Research Center of the Centre Hospitalier de l’Université Laval1and

2. Division of Microbiology,2Université Laval, Québec City, and

3. Department of Microbiology, Université de Montréal,3 and

4. Department of Medicine, McGill University,4 Montréal, Quebec, Canada

Abstract

ABSTRACT Specific human herpesvirus 8 (HHV-8) DNA sequences were found in leukocytes of 12 of 29 (41.4%) AIDS subjects with Kaposi’s sarcoma (KS), whereas they were found in 4 of 43 (9.3%) AIDS subjects without KS ( P = 0.003), although the peak HHV-8 DNA load in PCR-positive subjects with KS (mean, 425 copies per 0.2 μg of DNA) did not significantly differ from the one found in PCR-positive patients without KS (mean, 218 copies). The use of intravenous ganciclovir or foscarnet therapy to treat cytomegalovirus disease did not affect the HHV-8 DNA load in seven patients for whom serial samples were analyzed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.2.377

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