Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani-Reference-Cited by-同舟云学术

Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani

Published:1999-02 Issue:2 Volume:43 Page:390-392
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Petit C.¹,Yardley V.²,Gaboriau F.¹,Bolard J.¹,Croft S. L.²

Affiliation:

1. Laboratoire de Physicochimie Biomoléculaire et Cellulaire (CNRS ESA 7033), UniversitéPierre et Marie Curie, 75252 Paris cedex 05, France,1 and

2. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom2

Abstract

ABSTRACT The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.2.390

Reference28 articles.

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