Fungal Lethality, Binding, and Cytotoxicity of Syringomycin-E-Reference-Cited by-同舟云学术

Fungal Lethality, Binding, and Cytotoxicity of Syringomycin-E

Published:1999-02 Issue:2 Volume:43 Page:371-373
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

De Lucca A. J.¹,Jacks T. J.¹,Takemoto J.²,Vinyard B.³,Peter J.⁴,Navarro E.⁴,Walsh T. J.⁴

Affiliation:

1. Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, New Orleans, Louisiana1;

2. Department of Biology, Utah State University, Logan, Utah2;

3. Biometrical Consulting Service, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland3; and

4. Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland4

Abstract

ABSTRACT Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.2.371

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