Identification of Quorum-Sensing-Regulated Genes of Burkholderia cepacia

Author:

Aguilar Claudio1,Friscina Arianna1,Devescovi Giulia1,Kojic Milan1,Venturi Vittorio1

Affiliation:

1. Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy

Abstract

ABSTRACT Quorum sensing is a regulatory mechanism (operating in response to cell density) which in gram-negative bacteria usually involves the production of N -acyl homoserine lactones (HSL). Quorum sensing in Burkholderia cepacia has been associated with the regulation of expression of extracellular proteins and siderophores and also with the regulation of swarming and biofilm formation. In the present study, several quorum-sensing-controlled gene promoters of B. cepacia ATCC 25416 were identified and characterized. A total of 28 putative gene promoters show CepR-C 8 -HSL-dependent expression, suggesting that quorum sensing in B. cepacia is a global regulatory system.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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