Host Range of Chlamydiaphages φCPAR39 and Chp3

Author:

Everson J. S.1,Garner S. A.1,Lambden P. R.1,Fane B. A2,Clarke I. N.1

Affiliation:

1. Molecular Microbiology and Infection, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom

2. Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721-0090

Abstract

ABSTRACT The host range of φCPAR39 is limited to four Chlamydophila species: C. abortus , C. caviae , C. pecorum , and C. pneumoniae . Chp3 (a newly discovered bacteriophage isolated from C. pecorum ) shares three of these hosts ( C. abortus , C. caviae , and C. pecorum ) but can additionally infect Chlamydophila felis . The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that φCPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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