Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis

Author:

Cuchural G J,Tally F P,Storey J R,Malamy M H

Abstract

A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient. Cefoxitin-resistant transconjugants acquired a new beta-lactamase with a pI of 8.1 and were able to inactivate cefoxitin and retransfer cefoxitin resistance. No plasmids were detected in the donor or transconjugants.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference15 articles.

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4. Hanson R. S. and J. A. Phillips. 1981. Chemical composition p. 328-364. In P. Gerhardt R. G. E. Murray R. N. Costilow E. W. Nester W. A. Wood N. R. Krieg and G. B. Phillips (ed.) Manual of methods for general bacteriology. American Society for Microbiology Washington D.C.

5. P-Lactamase stability of cefoxitin in comparison with other P-lactam compounds;Neu H.;Diagn. Microbiol. Infect. Dis.,1983

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