Evidence of Localized Prophage-Host Recombination in the lytA Gene, Encoding the Major Pneumococcal Autolysin-Reference-Cited by-同舟云学术

Evidence of Localized Prophage-Host Recombination in the lytA Gene, Encoding the Major Pneumococcal Autolysin

Published:2010-05-15 Issue:10 Volume:192 Page:2624-2632
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Morales María¹²,García Pedro¹²,de la Campa Adela G.³²,Liñares Josefina⁴²,Ardanuy Carmen⁴²,García Ernesto¹²

Affiliation:

1. Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040 Madrid

2. CIBER de Enfermedades Respiratorias (CIBERES),Spain

3. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Crta. de Majadahonda a Pozuelo s/n, 28220 Majadahonda, Madrid

4. Institut d'Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona

Abstract

ABSTRACT According to a highly polymorphic region in the lytA gene, encoding the major autolysin of Streptococcus pneumoniae , two different families of alleles can be differentiated by PCR and restriction digestion. Here, we provide evidence that this polymorphic region arose from recombination events with homologous genes of pneumococcal temperate phages.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01501-09

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