Haemophilus influenzae Type b Carriage among Young Children in Metropolitan Atlanta in the Context of Vaccine Shortage and Booster Dose Deferral

Author:

Thomas Jennifer Dolan1,Jackson Michael L.1,Sharma Dolly23,Mair Raydel1,Bach Michelle C.14,Castillo Dana1,Ejigiri O. Grace1,Satola Sarah256,Cohn Amanda C.1,Jerris Robert23,Jain Shabnam23,Farley Monica M.256,Mayer Leonard W.1,Messonnier Nancy E.1

Affiliation:

1. Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, Georgia 30329

2. Emory University School of Medicine, 2015 Uppergate Drive, NE, Atlanta, Georgia 30322

3. Children's Healthcare of Atlanta, 1405 Clifton Road, NE, Atlanta, Georgia 30322

4. Biology Department, Agnes Scott College, 141 E. College Avenue, Decatur, Georgia 30030

5. Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, Georgia 30033

6. Georgia Emerging Infections Program, Atlanta VA Medical Center, 1670 Clairmont Road, Station 151, Decatur, Georgia 30033

Abstract

ABSTRACT Short-term deferral of the Haemophilus influenzae type b (Hib) vaccine booster dose during a recent U.S. Hib vaccine shortage did not result in widespread Hib carriage in Atlanta, as the Hib carriage rate was found to be 0.3% (1/342). Hib colonization was significantly more common among males and day care attendees.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Reference13 articles.

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2. Interim recommendations for the use of Haemophilus influenzae type b (Hib) conjugate vaccines related to the recall of certain lots of Hib-containing vaccines (PedvaxHIB and Comvax);Centers for Disease Control and Prevention;MMWR Morb. Mortal. Wkly. Rep.,2007

3. Continued shortage of Haemophilus influenzae type b (Hib) conjugate vaccines and potential implications for Hib surveillance—United States, 2008;Centers for Disease Control and Prevention;MMWR Morb. Mortal. Wkly. Rep.,2008

4. Updated recommendations for use of Haemophilus influenzae Type b (Hib) vaccine: reinstatement of the booster dose at ages 12-15 months;Centers for Disease Control and Prevention;Morb. Mortal. Wkly. Rep.,2009

5. DolanJ. M.. 2010. Real-time PCR assays for the detection of H. influenzae serotypes a, b, and f and sequencing of the capsule biosynthesis operons of serotypes c, d, and e, abstr. C-1589. Abstr. 110th Gen. Meet. Am. Soc. Microbiol. American Society for Microbiology, Washington, DC.

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