Serological Comparison of Spherules and Arthrospores of Coccidioides immitis-Reference-Cited by-同舟云学术

Serological Comparison of Spherules and Arthrospores of Coccidioides immitis

Published:1967-11 Issue:5 Volume:94 Page:1400-1405
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Landay Marshall E.¹²,Wheat Robert W.¹²,Conant Norman F.¹²,Lowe Edwin P.¹²

Affiliation:

1. Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27706

2. Department of Rickettsial Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20012

Abstract

Spherule and arthrospore cellular preparations were sonic-treated and separated into their respective supernatant and sediment components. Complement-fixation tests with antispherule and antiarthrospore pooled rabbit sera revealed that the soluble antigens exhibited more serological activity than the sediment preparations. After autoclaving, an arthrospore cellular antigen exhibited increased activity with either antisera, whereas autoclaved spherules exhibited increased activity only with antispherule serum. Complement-fixation tests with coccicioidin and spherule culture supernatant preparations revealed quantitative or qualitative differences in antigenic determinants between these two morphological phases of Coccidioides immitis .

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.94.5.1400-1405.1967

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