Entry of Herpes Simplex Virus Type 1 into Primary Sensory Neurons In Vitro Is Mediated by Nectin-1/HveC-Reference-Cited by-同舟云学术

Entry of Herpes Simplex Virus Type 1 into Primary Sensory Neurons In Vitro Is Mediated by Nectin-1/HveC

Published:2003-03 Issue:5 Volume:77 Page:3307-3311
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Richart Sarah M.¹,Simpson Scott A.²,Krummenacher Claude²³,Whitbeck J. Charles²³,Pizer Lewis I.²⁴,Cohen Gary H.²³,Eisenberg Roselyn J.³⁵,Wilcox Christine L.¹

Affiliation:

1. Department of Microbiology, Colorado State University, Fort Collins

2. Department of Microbiology

3. Center for Oral Health Research

4. Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado

5. School of Dental Medicine, and Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

ABSTRACT Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.5.3307-3311.2003

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