Hepatitis B Virus DNA in Blood Samples Positive for Antibodies to Core Antigen and Negative for Surface Antigen-Reference-Cited by-同舟云学术

Hepatitis B Virus DNA in Blood Samples Positive for Antibodies to Core Antigen and Negative for Surface Antigen

Published:1999-09 Issue:5 Volume:6 Page:768-770
ISSN:1071-412X
Container-title:Clinical Diagnostic Laboratory Immunology
language:en
Short-container-title:Clin Diagn Lab Immunol

Author:

Gutiérrez C.¹,León G.²,Loureiro C. L.¹,Uzcátegui N.¹,Liprandi F.¹,Pujol F. H.¹

Affiliation:

1. Laboratorio de Biologı́a de Virus, Centro de Microbiologı́a y Biologı́a Cellular, Instituto Venezolano de Investigaciones Cientı́ficas, Apartado 21827, Caracas 1020-A,1 and

2. Banco Municipal de Sangre, Caracas,2 Venezuela

Abstract

ABSTRACT Anti-hepatitis B core antigen (HBcAg)-positive hepatitis B surface antigen (HBsAg)-negative plasma samples from blood donors were tested by nested PCR. DNA positivity was more significantly associated with high levels of anti-HBcAg than with low levels of anti-HBsAg antibodies. Analysis of a dilution of anti-HBcAg antibodies might result in a more rational exclusion of anti-HBcAg-positive HBsAg-negative samples, reducing the number of donations discarded and enabling more countries to incorporate anti-HBcAg testing.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.6.5.768-770.1999

Reference23 articles.

1. Antigenic diversity of hepatitis B virus strains of genotype F in Amerindians and other population groups from Venezuela.;Blitz L.;J. Clin. Microbiol.,1998

2. Vaccine-induced escape mutant of hepatitis B virus.;Carman W. F.;Lancet,1990

3. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA.;Carman W. F.;Lancet,1995

4. Absence of hepatitis B virus DNA detected by polymerase chain reaction in blood donors who are hepatitis B surface antigen negative and antibody to hepatitis B core antigen positive from a United States population with a low prevalence of hepatitis B serologic markers.;Douglas D. D.;Transfusion,1992

5. Detection of hepatitis B virus DNA in hepatitis B surface antigen-negative serum by polymerase chain reaction: evaluation of different primer pairs and conditions.;Gomes S. A.;Acta Virol.,1996

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Decreasing prevalence of Hepatitis B and absence of Hepatitis C Virus infection in the Warao indigenous population of Venezuela;PLOS ONE;2018-05-25

2. Are current screening protocols for chronic hepatitis B virus infection adequate?;Diagnostic Microbiology and Infectious Disease;2016-06

3. Occult Hepatitis B virus infection Among blood donors in Colombia;Virology Journal;2014-11-29

4. Detección de hepatitis B oculta en donantes de bancos sangre, Colombia 2008-2009;Biomédica;2011-06-30

5. Molecular and serological characterization of occult hepatitis B infection in blood donors from Mexico;Annals of Hepatology;2011-04