Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations-Reference-Cited by-同舟云学术

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wiederhold Nathan P.¹^ORCID,Schwartz Ilan S.²^ORCID,Patterson Thomas F.³⁴,Thompson George R.⁵⁶⁷^ORCID

Affiliation:

1. Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

2. Division of Infectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

3. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

4. South Texas Veterans Health Care System, San Antonio, Texas, USA

5. Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, Sacramento, California, USA

6. Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA

7. UC-Davis Center for Coccidioidomycosis, Davis, California, USA

Abstract

We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02353-20

Reference27 articles.

1. Clinical Practice Guidelines for the Management of Blastomycosis: 2008 Update by the Infectious Diseases Society of America

2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

3. Endemic fungal infections in solid organ transplant recipients—Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

4. Update on Therapeutic Drug Monitoring of Antifungals for the Prophylaxis and Treatment of Invasive Fungal Infections

5. Antifungal Therapeutic Drug Monitoring: Established and Emerging Indications

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antifungal Therapies for Aspergillus spp.: Present and Future;Seminars in Respiratory and Critical Care Medicine;2023-12-27

2. Antifungal Therapeutic Drug Monitoring Practices: Results of an Emerging Infections Network Survey;Open Forum Infectious Diseases;2023-09-01

3. Low Rates of Antifungal Therapeutic Drug Monitoring Among Inpatients Who Received Itraconazole, Posaconazole, or Voriconazole, United States, 2019–2021;Open Forum Infectious Diseases;2023-07-20

4. Does metabolite matter? Defining target itraconazole and hydroxy‐itraconazole serum concentrations for blastomycosis;Mycoses;2023-01-25

5. Azole Therapeutic Drug Monitoring and its Use in the Management of Invasive Fungal Disease;Current Fungal Infection Reports;2022-03-11