Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations-Reference-Cited by-同舟云学术

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wiederhold Nathan P.¹^ORCID,Schwartz Ilan S.²^ORCID,Patterson Thomas F.³⁴,Thompson George R.⁵⁶⁷^ORCID

Affiliation:

1. Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

2. Division of Infectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

3. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

4. South Texas Veterans Health Care System, San Antonio, Texas, USA

5. Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, Sacramento, California, USA

6. Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA

7. UC-Davis Center for Coccidioidomycosis, Davis, California, USA

Abstract

We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02353-20

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