Single-Cell RNA Sequencing Reveals Unique Alterations in the Immune Panorama and Treg Subpopulations in Mice during the Late Stages of Echinococcus granulosus Infection

Author:

Wu Jianwen12ORCID,Xiao Jing13,Bai Min12,Shi Chunli4,Xin Yunzhuo12,Zhao Wei1562,Gao Xiaoping7,Yin Mei8,Zhao Jiaqing1562ORCID

Affiliation:

1. School of Basic Medicine, Ningxia Medical University, Yinchuan, China

2. Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases, Yinchuan, China

3. Shiyan Integrated Traditional Chinese and Western Medicine Hospital, Shiyan, China

4. Department of Molecular Biology, Shanghai Centre for Clinical Laboratory, Shanghai, China

5. Research Center for Medical Science and Technology, Ningxia Medical University, Yinchuan, China

6. Ningxia Institute of Medical Science, Yinchuan, China

7. Department of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, China

8. Department of Respiratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, China

Abstract

Cystic echinococcosis (CE) is a common zoonotic parasitic disease that seriously impacts public health. However, the full spectrum of immune cell changes in Echinococcus granulosus infection, especially the negative immune regulation of subpopulations of regulatory T (Treg) cells, are not yet well understood.

Funder

National Natural Science Foundation of China

The ningxia national science found project

宁夏回族自治区科学技术厅 | Key Research and Development Program of Ningxia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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