Lymphotoxin β Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii

Author:

Tersteegen Anne12ORCID,Sorg Ursula R.1,Virgen-Slane Richard3,Helle Marcel1,Petzsch Patrick4,Dunay Ildiko R.2,Köhrer Karl4,Degrandi Daniel1ORCID,Ware Carl F.3,Pfeffer Klaus1ORCID

Affiliation:

1. Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany

2. Institute of Inflammation and Neurodegeneration, Otto-von-Guericke-University, Magdeburg, Germany

3. Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

4. Biological and Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany

Abstract

The lymphotoxin β receptor (LTβR) plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTβR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete.

Funder

Juergen Manchot Foundation

Perkins Family Foundation

Perkins Family Foundation fellowship

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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