Hepatitis G Virus Encodes Protease Activities Which Can Effect Processing of the Virus Putative Nonstructural Proteins-Reference-Cited by-同舟云学术

Hepatitis G Virus Encodes Protease Activities Which Can Effect Processing of the Virus Putative Nonstructural Proteins

Published:1998-01 Issue:1 Volume:72 Page:868-872
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Belyaev Alexander S.¹,Chong Susan¹,Novikov Alexander¹,Kongpachith Ana¹,Masiarz Frank R.²³,Lim Moon¹,Kim Jungsuh P.¹

Affiliation:

1. Genelabs Technologies, Inc., Redwood City, California 940631;

2. Protein Structure Analysis Group, Chiron Corporation, Emeryville, California 94608-29162; and

3. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 941433

Abstract

ABSTRACT The genome of a recently identified virus, hepatitis G virus (HGV), shows considerable homology to hepatitis C virus (HCV). Two HGV proteases similar to nonstructural proteins NS2 and NS3 of HCV were identified, and their cleavage site specificity was investigated. Amino acids essential for the protease activities were determined by mutation analysis. NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu 1561 and Ala 1598 .

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.1.868-872.1998

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