Exchange of Viral Promoter/Enhancer Elements with Heterologous Regulatory Sequences Generates Targeted Hybrid Long Terminal Repeat Vectors for Gene Therapy of Melanoma-Reference-Cited by-同舟云学术

Exchange of Viral Promoter/Enhancer Elements with Heterologous Regulatory Sequences Generates Targeted Hybrid Long Terminal Repeat Vectors for Gene Therapy of Melanoma

Published:1998-01 Issue:1 Volume:72 Page:789-795
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Diaz R. M.¹,Eisen T.²,Hart I. R.¹,Vile R. G.³

Affiliation:

1. Richard Dimbleby Department of Cancer Research/ICRF Laboratory, Rayne Institute, St. Thomas’ Hospital, London SE1 7EH,1

2. Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL,2and

3. ICRF Laboratory of Molecular Therapy, ICRF Oncology Unit, Hammersmith Hospital, London W12 0NN,3 United Kingdom

Abstract

ABSTRACT To generate transcriptionally targeted vectors, tissue-specific elements of the human tyrosinase promoter were exchanged with corresponding viral elements in the Moloney murine leukemia virus long terminal repeat (LTR). From these experiments, a vesicular stomatitis virus type G pseudotyped, hybrid LTR vector that contained three tyrosinase enhancer elements and gave high-level, tightly tissue-specific expression at high titers (3 × 10 7 CFU/ml) was constructed.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.1.789-795.1998

Reference40 articles.

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