Affiliation:
1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38101-0318
Abstract
ABSTRACT
The primary CD8
+
T-cell response protected most B-cell-deficient μMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8
+
T-cell response cleared the virus from the lung within 7 days. Depleting the CD8
+
T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4
+
T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4
+
T-cell responses is relatively inefficient in the absence of B cells and CD8
+
T cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
143 articles.
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