Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques-Reference-Cited by-同舟云学术

Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques

Published:1998-01 Issue:1 Volume:72 Page:164-169
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Matano Tetsuro¹,Shibata Riri¹,Siemon Christine¹,Connors Mark²,Lane H. Clifford²,Martin Malcolm A.¹

Affiliation:

1. Laboratory of Molecular Microbiology1 and

2. Laboratory of Immunoregulation,2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460

Abstract

ABSTRACT Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8 + cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8 + T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.1.164-169.1998

Reference35 articles.

1. Purification of immunoglobulin G;Andrew S. M.;Current protocols in immunology,1997

2. CD28− T lymphocytes;Azuma M.;J. Immunol.,1993

3. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

4. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28− T cells;Borthwick N. J.;AIDS,1994

5. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations;Brinchmann J. E.;J. Infect. Dis.,1994

Cited by 432 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure;AIDS Research and Human Retroviruses;2024-01-01

2. CD8+ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production;Nature Communications;2023-10-20

3. Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection;2023-10-14

4. The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection;Immunity;2023-04

5. Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251;Nature Communications;2023-03-07