The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses-Reference-Cited by-同舟云学术

The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses

Published:1998-01 Issue:1 Volume:72 Page:415-419
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bergelson Jeffrey M.¹,Krithivas Anita¹,Celi Leo¹,Droguett Gustavo²,Horwitz Marshall S.²³,Wickham Thomas⁴,Crowell Richard L.⁵,Finberg Robert W.¹

Affiliation:

1. Division of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 021151;

2. Departments of Microbiology-Immunology2and

3. Pediatrics,3 Albert Einstein College of Medicine, Bronx, New York 10461;

4. GenVec, Inc., Rockville, Maryland 208524; and

5. Department of Microbiology and Immunology, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania 191025

Abstract

ABSTRACT Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.1.415-419.1998

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