SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells-Reference-Cited by-同舟云学术

SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Meyer Keith¹^ORCID,Patra Tapas¹^ORCID,Vijayamahantesh ¹,Ray Ranjit¹²^ORCID

Affiliation:

1. Department of Internal Medicine, Saint Louis University, Missouri, USA

2. Department of Molecular Microbiology & Immunology, Saint Louis University, Missouri, USA

Abstract

The present study was aimed at examining the underlying mechanism of extrapulmonary manifestations of SARS-CoV-2 spike protein-associated pathogenesis, with the notion that infection of the pulmonary epithelium can lead to mediators that drive endothelial dysfunction. We utilized SARS-CoV-2 spike protein expression in cultured human hepatocytes (Huh7.5) and pneumocytes (A549) to generate conditioned culture medium (CM).

Funder

Saint Louis University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00794-21

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