Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells

Author:

Anand Sai Priya12,Ding Shilei1,Tolbert William D.3,Prévost Jérémie14,Richard Jonathan14,Gil Hwi Min56,Gendron-Lepage Gabrielle1,Cheung Wing-Fai7,Wang Haifeng7,Pastora Rebecca7,Saxena Hirak8,Wakarchuk Warren8ORCID,Medjahed Halima1,Wines Bruce D.91011,Hogarth Mark91011,Shaw George M.12ORCID,Martin Malcom A.13,Burton Dennis R.1415,Hangartner Lars14,Evans David T.56ORCID,Pazgier Marzena3ORCID,Cossar Doug7,McLean Michael D.7,Finzi Andrés124ORCID

Affiliation:

1. Centre de Recherche du CHUM, Montreal, Quebec, Canada

2. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

3. Infectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

4. Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montreal, Quebec, Canada

5. Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA

6. Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA

7. PlantForm Corporation, Toronto, Ontario, Canada

8. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

9. Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia

10. Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia

11. Department of Immunology and Pathology Monash University, Melbourne, VIC, Australia

12. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

13. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

14. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA

15. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard University, Cambridge, Massachusetts, USA

Abstract

PGT121 is a highly potent bNAb and its antiviral activities for HIV-1 prevention and therapy are currently being evaluated in clinical trials. The importance of its Fc-effector functions in clearing HIV-1-infected cells is also under investigation.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | National Research Council Canada

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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