Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment-Reference-Cited by-同舟云学术

Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tang Girdwood Sonya¹²³^ORCID,Dong Min²³^ORCID,Tang Peter³⁴,Stoneman Erin⁵,Jones Rhonda⁵,Yunger Toni⁵,Ostermeier Austin¹³,Curry Calise¹,Forton Melissa¹,Hail Traci¹,Mullaney Randi¹,Lahni Patrick⁵^ORCID,Punt Nieko⁶⁷^ORCID,Kaplan Jennifer³⁵^ORCID,Vinks Alexander A.²³^ORCID

Affiliation:

1. Division of Hospital Medicine, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

2. Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

4. Division of Pathology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

5. Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

6. Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

7. Medimatics, Maastricht, the Netherlands

Abstract

Critical illness, including sepsis, causes significant pathophysiologic changes that alter the pharmacokinetics (PK) of antibiotics. Ceftriaxone is one of the most prescribed antibiotics in patients admitted to the pediatric intensive care unit (PICU).

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Center for Advancing Translational Sciences

Cincinnati Children's Hospital Medical Center

Gerber Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01427-21

Reference40 articles.