Extended Culture Enhances Sensitivity of a Gamma Interferon Assay for Latent Mycobacterium tuberculosis Infection-Reference-Cited by-同舟云学术

Extended Culture Enhances Sensitivity of a Gamma Interferon Assay for Latent Mycobacterium tuberculosis Infection

Published:2007-06 Issue:6 Volume:14 Page:796-798
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Cehovin Ana¹²,Cliff Jacqueline M.¹²,Hill Philip C.¹²,Brookes Roger H.¹²,Dockrell Hazel M.¹²

Affiliation:

1. Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

2. Medical Research Centre, The Fajara, Banjul, The Gambia

Abstract

ABSTRACT To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis -specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00093-07

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