Fusion of Erythrocytes by Sendai Virus Studied by Immuno-Freeze-Etching

Author:

Bächi Thomas12,Aguet Michel12,Howe Calderon12

Affiliation:

1. Division of Experimental Microbiology, Institute for Medical Microbiology, University of Zürich, Switzerland

2. Department of Microbiology, Louisiana State University Medical Center, New Orleans, Louisiana 70112

Abstract

Extensive fusion of human erythrocytes agglutinated by Sendai virus was observed after 30 s of incubation at 37 C. Electron microscopy of thin sections failed to reveal the presence of virions, viral fragments, or discrete viral antigens reactive with ferritin-labeled antibody at the sites of fusion. Immuno-freezeetching of membrane surfaces demonstrated the dispersal of viral envelope antigens from what appeared to be original sites of viral attachment. Virus-induced clustering of membrane glycoproteins was interpreted as resulting from interaction of viral antigens with membrane receptor proteins and forming the structural basis for fusion of membranes with one another.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference20 articles.

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2. Interaction of Sendai (HVJ) virus with human erythrocytes: a morphological study of haemolysis cell fusion;Apostolov K.;J. Gen. Virol.,1972

3. Fusion of erythrocytes by Sendai virus studied by electron microscopy;Bachi T.;Proc. Soc. Exp. Biol. Med.,1972

4. Fusion of human red blood cell membranes;Baker R. F.;J. Cell Biol.,1970

5. Konjugation von Ferritin mit Anti-Kaninchen-Saccharase Immunglobulin-G;Binz H.;Pathol. Microbiol.,1969

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